GO Term : GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

10158 Ontology Annotations

Class GO Term Gene Name Db
GOAnnotation GO:0004489 177964  
OntologyAnnotation GO:0004489 177964 GO
GOAnnotation GO:0004489 140106  
OntologyAnnotation GO:0004489 140106 GO
OntologyAnnotation GO:0004489 evm.model.supercontig_9.233 GO
GOAnnotation GO:0004489 evm.TU.supercontig_9.233  
OntologyAnnotation GO:0004489 28966.m000545 GO
GOAnnotation GO:0004489 28966.t000024  
OntologyAnnotation GO:0004489 29299.m000045 GO
GOAnnotation GO:0004489 29299.t000001  
OntologyAnnotation GO:0004489 Cucsa.194120.3 GO
OntologyAnnotation GO:0004489 Cucsa.194120.2 GO
GOAnnotation GO:0004489 Cucsa.194120  
OntologyAnnotation GO:0004489 Cucsa.194120.1 GO
OntologyAnnotation GO:0004489 orange1.1g008423m GO
GOAnnotation GO:0004489 orange1.1g008423m.g  
OntologyAnnotation GO:0004489 AT2G44160.1 GO
GOAnnotation GO:0004489 AT2G44160  
OntologyAnnotation GO:0004489 AT3G59970.2 GO
GOAnnotation GO:0004489 AT3G59970  
OntologyAnnotation GO:0004489 AT3G59970.1 GO
OntologyAnnotation GO:0004489 AT3G59970.3 GO
OntologyAnnotation GO:0004489 Thhalv10005854m GO
GOAnnotation GO:0004489 Thhalv10005854m.g  
GOAnnotation GO:0004489 Thhalv10001367m.g  
OntologyAnnotation GO:0004489 Thhalv10001367m GO
GOAnnotation GO:0004489 Ciclev10019406m.g  
OntologyAnnotation GO:0004489 Ciclev10019406m GO
OntologyAnnotation GO:0004489 Ciclev10019489m GO
GOAnnotation GO:0004489 Lus10025610.g  

11 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0044710 single-organism metabolic process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.

18 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016646 GO:0004489
part of GO:0044710 GO:0004489
part of GO:0044699 GO:0004489
part of GO:0055114 GO:0004489
is_a GO:0016645 GO:0004489
part of GO:0008150 GO:0004489
part of GO:0008152 GO:0004489
is_a GO:0003674 GO:0004489
is_a GO:0016491 GO:0004489
is_a GO:0003824 GO:0004489
regulates GO:0004489 GO:1903868
regulates GO:0004489 GO:1903868
negatively regulates GO:0004489 GO:1903869
negatively regulates GO:0004489 GO:1903869
regulates GO:0004489 GO:1903869
positively regulates GO:0004489 GO:1903870
positively regulates GO:0004489 GO:1903870
regulates GO:0004489 GO:1903870

31 Synonyms

Name Type
methylenetetrahydrofolate reductase (NADPH2) synonym
methylenetetrahydrofolate reductase (NADPH(2)) activity synonym
methylenetetrahydrofolate reductase activity synonym
methylenetetrahydrofolate reductase [NAD(P)H] synonym
MTHFR activity synonym
methylenetetrahydrofolic acid reductase activity synonym
N(5,10)-methylenetetrahydrofolate reductase activity synonym
N(5),N(10)-methylenetetrahydrofolate reductase activity synonym
N5,N10-methylenetetrahydrofolate reductase activity synonym
N5,10-methylenetetrahydrofolate reductase activity synonym
GO:0008702 alt_id
1.7.99.5 synonym
5,10-methylenetetrahydrofolate reductase activity synonym
5,10-CH2-H4folate reductase activity synonym
5,10-CH(2)-H(4)folate reductase activity synonym
5,10-methylenetetrahydrofolate reductase (FADH) activity synonym
5,10-methylenetetrahydrofolate reductase (FADH(2)) activity synonym
5,10-methylenetetrahydrofolate reductase (NADPH) activity synonym
5,10-methylenetetrahydrofolate reductase (FADH2) activity synonym
5,10-methylenetetrahydropteroylglutamate reductase activity synonym
5,10-methylenetetrahydrofolic acid reductase activity synonym
5-methyltetrahydrofolate:NAD oxidoreductase activity synonym
5-methyltetrahydrofolate:(acceptor) oxidoreductase activity synonym
5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity synonym
5-methyltetrahydrofolate:NAD(+) oxidoreductase activity synonym
5-methyltetrahydrofolate:NADP(+) oxidoreductase activity synonym
5-methyltetrahydrofolate:NAD+ oxidoreductase activity synonym
MetF synonym
5-methyltetrahydrofolate:NADP+ oxidoreductase activity synonym
methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity synonym