GO Term : GO:0004844 uracil DNA N-glycosylase activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

891 Ontology Annotations

Class GO Term Gene Name Db
GOAnnotation GO:0004844 46714  
OntologyAnnotation GO:0004844 46714 GO
GOAnnotation GO:0004844 66695  
OntologyAnnotation GO:0004844 66695 GO
OntologyAnnotation GO:0004844 78447 GO
GOAnnotation GO:0004844 78447  
GOAnnotation GO:0004844 evm.TU.supercontig_0.166  
OntologyAnnotation GO:0004844 evm.model.supercontig_0.166 GO
OntologyAnnotation GO:0004844 29725.m000234 GO
GOAnnotation GO:0004844 29725.t000003  
GOAnnotation GO:0004844 Cucsa.373300  
OntologyAnnotation GO:0004844 Cucsa.373300.1 GO
OntologyAnnotation GO:0004844 orange1.1g038649m GO
GOAnnotation GO:0004844 orange1.1g038649m.g  
OntologyAnnotation GO:0004844 orange1.1g047176m GO
GOAnnotation GO:0004844 orange1.1g047176m.g  
GOAnnotation GO:0004844 AT2G10550  
OntologyAnnotation GO:0004844 AT2G10550.1 GO
GOAnnotation GO:0004844 AT3G18630  
OntologyAnnotation GO:0004844 AT3G18630.1 GO
OntologyAnnotation GO:0004844 Thhalv10021116m GO
GOAnnotation GO:0004844 Thhalv10021116m.g  
OntologyAnnotation GO:0004844 Ciclev10006661m GO
GOAnnotation GO:0004844 Ciclev10006661m.g  
GOAnnotation GO:0004844 Lus10012898.g  
OntologyAnnotation GO:0004844 Lus10012898 GO
OntologyAnnotation GO:0004844 Lus10030553 GO
GOAnnotation GO:0004844 Lus10030553.g  
OntologyAnnotation GO:0004844 Potri.010G169600.2 GO
OntologyAnnotation GO:0004844 Potri.010G169600.1 GO

10 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond.
GO:0016798 hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond.
GO:0004844 uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
GO:0019104 DNA N-glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0097506 deaminated base DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated bases.

11 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0097506 GO:0004844
is_a GO:0019104 GO:0004844
part of GO:0008150 GO:0004844
is_a GO:0016799 GO:0004844
part of GO:0008152 GO:0004844
is_a GO:0016798 GO:0004844
is_a GO:0016787 GO:0004844
is_a GO:0003674 GO:0004844
is_a GO:0003824 GO:0004844
is_a GO:0004844 GO:0017065
is_a GO:0004844 GO:0043739

1 Synonyms

Name Type
uracil-DNA glycosylase activity synonym