GO Term : GO:0003905 alkylbase DNA N-glycosylase activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

810 Ontology Annotations

Class GO Term Gene Name Db
OntologyAnnotation GO:0003905 232080 GO
GOAnnotation GO:0003905 232080  
GOAnnotation GO:0003905 evm.TU.supercontig_2.64  
OntologyAnnotation GO:0003905 evm.model.supercontig_2.64 GO
OntologyAnnotation GO:0003905 evm.model.supercontig_85.61 GO
GOAnnotation GO:0003905 evm.TU.supercontig_85.61  
OntologyAnnotation GO:0003905 28582.m000324 GO
GOAnnotation GO:0003905 28582.t000009  
GOAnnotation GO:0003905 Cucsa.242540  
OntologyAnnotation GO:0003905 Cucsa.242540.1 GO
OntologyAnnotation GO:0003905 Cucsa.242540.2 GO
OntologyAnnotation GO:0003905 orange1.1g031868m GO
OntologyAnnotation GO:0003905 orange1.1g029132m GO
GOAnnotation GO:0003905 orange1.1g029132m.g  
GOAnnotation GO:0003905 AT3G12040  
OntologyAnnotation GO:0003905 AT3G12040.1 GO
GOAnnotation GO:0003905 Thhalv10021378m.g  
OntologyAnnotation GO:0003905 Thhalv10021378m GO
OntologyAnnotation GO:0003905 Ciclev10012694m GO
OntologyAnnotation GO:0003905 Ciclev10012466m GO
GOAnnotation GO:0003905 Ciclev10012466m.g  
OntologyAnnotation GO:0003905 Lus10017241 GO
GOAnnotation GO:0003905 Lus10017241.g  
GOAnnotation GO:0003905 Lus10021071.g  
OntologyAnnotation GO:0003905 Lus10021071 GO
OntologyAnnotation GO:0003905 Potri.016G060000.1 GO
GOAnnotation GO:0003905 Potri.016G060000  
OntologyAnnotation GO:0003905 Potri.016G060000.2 GO
GOAnnotation GO:0003905 Gorai.012G099400  
OntologyAnnotation GO:0003905 Gorai.012G099400.2 GO

9 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond.
GO:0016798 hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond.
GO:0003905 alkylbase DNA N-glycosylase activity Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.
GO:0019104 DNA N-glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

18 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0019104 GO:0003905
part of GO:0008152 GO:0003905
is_a GO:0016798 GO:0003905
is_a GO:0016787 GO:0003905
is_a GO:0016799 GO:0003905
is_a GO:0003824 GO:0003905
is_a GO:0003674 GO:0003905
part of GO:0008150 GO:0003905
is_a GO:0003905 GO:0008725
is_a GO:0003905 GO:0043733
is_a GO:0003905 GO:0043916
is_a GO:0003905 GO:0052820
is_a GO:0003905 GO:0052821
is_a GO:0003905 GO:0052822
regulates GO:0003905 GO:1901971
regulates GO:0003905 GO:1901972
positively regulates GO:0003905 GO:1901972
is_a GO:0003905 GO:1990053

9 Synonyms

Name Type
alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine) synonym
AlkA synonym
3-methyladenine DNA glycosylase II synonym
alkylbase DNA glycosidase activity synonym
DNA glycosidase II activity synonym
deoxyribonucleate 3-methyladenine glycosidase II synonym
DNA-3-methyladenine glycosylase II synonym
DNA-3-methyladenine glycosidase II activity synonym
GO:0004036 alt_id