GO Term : GO:0005085 guanyl-nucleotide exchange factor activity GO

Namespace:  molecular_function Obsolete:  false
description  Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

10158 Ontology Annotations

Class GO Term Gene Name Db
GOAnnotation GO:0005085 129262  
OntologyAnnotation GO:0005085 129262 GO
GOAnnotation GO:0005085 evm.TU.supercontig_34.42  
OntologyAnnotation GO:0005085 evm.model.supercontig_34.44 GO
OntologyAnnotation GO:0005085 evm.model.supercontig_34.43 GO
GOAnnotation GO:0005085 evm.TU.supercontig_34.44  
GOAnnotation GO:0005085 evm.TU.supercontig_34.43  
OntologyAnnotation GO:0005085 evm.model.supercontig_34.42 GO
GOAnnotation GO:0005085 evm.TU.supercontig_71.2  
OntologyAnnotation GO:0005085 evm.model.supercontig_71.2 GO
GOAnnotation GO:0005085 30024.t000059  
OntologyAnnotation GO:0005085 30024.m001742 GO
GOAnnotation GO:0005085 Cucsa.239810  
OntologyAnnotation GO:0005085 Cucsa.239810.1 GO
OntologyAnnotation GO:0005085 Cucsa.239810.2 GO
OntologyAnnotation GO:0005085 orange1.1g000652m GO
OntologyAnnotation GO:0005085 orange1.1g000651m GO
GOAnnotation GO:0005085 orange1.1g000651m.g  
OntologyAnnotation GO:0005085 orange1.1g001401m GO
OntologyAnnotation GO:0005085 AT4G16340.1 GO
GOAnnotation GO:0005085 AT4G16340  
GOAnnotation GO:0005085 Thhalv10024194m.g  
OntologyAnnotation GO:0005085 Thhalv10024194m GO
GOAnnotation GO:0005085 Thhalv10022185m.g  
OntologyAnnotation GO:0005085 Thhalv10022185m GO
OntologyAnnotation GO:0005085 Ciclev10010893m GO
OntologyAnnotation GO:0005085 Ciclev10010906m GO
GOAnnotation GO:0005085 Ciclev10010893m.g  
OntologyAnnotation GO:0005085 Lus10013253 GO
GOAnnotation GO:0005085 Lus10013253.g  

36 Parents

Identifier Name Description
GO:0000166 nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
GO:0019001 guanyl nucleotide binding Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate.
GO:0032549 ribonucleoside binding Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.
GO:0001882 nucleoside binding Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.
GO:0043085 positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme.
GO:0017076 purine nucleotide binding Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0005085 guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
GO:0036094 small molecule binding Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.
GO:0043167 ion binding Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
GO:0097367 carbohydrate derivative binding Interacting selectively and non-covalently with a carbohydrate derivative.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:1901363 heterocyclic compound binding Interacting selectively and non-covalently with heterocyclic compound.
GO:0097159 organic cyclic compound binding Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
GO:0043168 anion binding Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:1901265 nucleoside phosphate binding Interacting selectively and non-covalently with nucleoside phosphate.
GO:0048518 positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0044093 positive regulation of molecular function Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009893 positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0098772 molecular function regulator A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators.
GO:0001883 purine nucleoside binding Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.
GO:0032553 ribonucleotide binding Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
GO:0032555 purine ribonucleotide binding Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

52 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0043547 GO:0005085
is_a GO:0098772 GO:0005085
negatively regulates GO:0019003 GO:0005085
part of GO:0043087 GO:0005085
negatively regulates GO:0032561 GO:0005085
part of GO:0043085 GO:0005085
part of GO:0048518 GO:0005085
part of GO:0044093 GO:0005085
negatively regulates GO:0032549 GO:0005085
part of GO:0009893 GO:0005085
part of GO:0065009 GO:0005085
negatively regulates GO:0097159 GO:0005085
negatively regulates GO:0017076 GO:0005085
negatively regulates GO:0036094 GO:0005085
negatively regulates GO:0000166 GO:0005085
negatively regulates GO:0003674 GO:0005085
part of GO:0050789 GO:0005085
negatively regulates GO:0032550 GO:0005085
part of GO:0019222 GO:0005085
negatively regulates GO:0032553 GO:0005085
part of GO:0051336 GO:0005085
negatively regulates GO:1901363 GO:0005085
negatively regulates GO:1901265 GO:0005085
part of GO:0008150 GO:0005085
part of GO:0065007 GO:0005085
negatively regulates GO:0032555 GO:0005085
negatively regulates GO:0019001 GO:0005085
negatively regulates GO:0043167 GO:0005085
negatively regulates GO:0043168 GO:0005085
negatively regulates GO:0097367 GO:0005085

9 Synonyms

Name Type
GO:0008433 alt_id
GO:0016219 alt_id
guanyl-nucleotide release factor activity synonym
guanyl-nucleotide releasing factor synonym
GO:0019839 alt_id
GEF synonym
GNRP synonym
GDP-dissociation stimulator activity synonym
GDS synonym