Protein Domain : IPR031099

Type:  Family Name:  BRCA1-associated
Description:  This entry includes animal BRCA1 (BREAST CANCER SUSCEPTIBILITY 1) proteins and their homologues from plants [].The aimal BRCA1 protein is a E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage [, ]. It contains an N-terminal zinc-finger domain. It also contains a BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain []. Arabidopsis BRCA1-related proteins includes AtBRCA1(AT4G21070, ) and AtBARD1 (AT1G04020, ). Both are involved in DNA repair in plants [, ]. AtBRCA1 can be induced by gamma-rays []. AtBARD1, also known as Row1, functions mainly as a REPRESSOR OF WUSCHEL1, which is a transcription repressor required to regulate the maintenance of stem cell populations in shoot meristems [, ]. Short Name:  BRCA1-associated
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1 Child Features

DB identifier Type Name
IPR011364 Family Breast cancer type 1 susceptibility protein (BRCA1)

0 Contains

1 Cross References

Identifier
PTHR13763:SF0

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0006281 IPR031099
GO:0006974 IPR031099

2 Ontology Annotations

GO Term Gene Name
GO:0006281 IPR031099
GO:0006974 IPR031099

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zosma01g38440 A0A0K9PK17 PAC:50094686 Zostera marina 773  
Zosma03g23680 PAC:50108253 Zostera marina 1520  
Zosma05g29400 PAC:50105545 Zostera marina 703  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14576433
            10500182
            10724175
            22629260
            25527727
            19704708
            25631790
            12582233
            16957774