Protein Domain : IPR011364

Type:  Family Name:  Breast cancer type 1 susceptibility protein (BRCA1)
Description:  Breast cancer is a common malignancy, affecting 1 in 8 women. A major contributary factor in disease development lies in a positive family history, a correlation that is striking for early-onset breast cancer. Mutations in the DNA-damage repair protein BRCA1 [,] are believed to be responsible for 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer.The BRCA1 protein is a E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage [, ]. It contains an N-terminal zinc-finger domain. It also contains a BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain []. Short Name:  BRCA1
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0 Child Features

4 Contains

DB identifier Type Name
IPR001841 Domain Zinc finger, RING-type
IPR018957 Domain Zinc finger, C3HC4 RING-type
IPR001357 Domain BRCT domain
IPR017907 Conserved_site Zinc finger, RING-type, conserved site

2 Cross Referencess

Identifier
PIRSF001734
PR00493

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR011364
GO:0004842 IPR011364
GO:0008270 IPR011364
GO:0006281 IPR011364
GO:0005634 IPR011364

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR011364
GO:0004842 IPR011364
GO:0008270 IPR011364
GO:0006281 IPR011364
GO:0005634 IPR011364

1 Parent Features

DB identifier Type Name
IPR031099 Family BRCA1-associated

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Spipo13G0044700 PAC:31519258 Spirodela polyrhiza 307  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10198641
            8232556
            14576433
            10500182
            10724175