Protein Domain : IPR001841

Type:  Domain Name:  Zinc finger, RING-type
Description:  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents RING-type zinc finger domains. The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc, and is probably involved in mediating protein-protein interactions [, , ]. There are two different variants, the C3HC4-type and a C3H2C3-type, which are clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as 'RING-H2 finger'. The RING domain is a protein interaction domain that has been implicated in a range of diverse biological processes. E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain. E3 ubiquitin-protein ligases determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. More recently, however, U-box proteins, which contain a domain (the U box) of about 70 amino acids that is conserved from yeast to humans, have been identified as a new type of E3 []. Various RING fingers also exhibit binding to E2 ubiquitin-conjugating enzymes (Ubc's) [, , ].Several 3D-structures for RING-fingers are known [, ]. The 3D structure of the zinc ligation system is unique to the RING domain and is referred to as the 'cross-brace' motif. The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion, whilst pairs two and four bind the second.Note that in the older literature, some RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family, albeit with similar Cys-spacing (see ). Short Name:  Znf_RING
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3 Child Features

DB identifier Type Name
IPR027934 Domain Cellulose synthase, RING-type zinc finger
IPR027370 Domain RING-type zinc-finger, LisH dimerisation motif
IPR024766 Domain Zinc finger, RING-H2-type

1 Contains

DB identifier Type Name
IPR017907 Conserved_site Zinc finger, RING-type, conserved site

4 Cross Referencess

Identifier
PF13639
PF14634
PS50089
SM00184

18 Found Ins

DB identifier Type Name
IPR016528 Family Vacuolar protein sorting-associated protein 11
IPR017375 Family Peroxisome assembly protein 12
IPR004162 Family E3 ubiquitin-protein ligase SIN-like
IPR016902 Family Vacuolar protein sorting-associated protein 41
IPR004575 Family Cdk-activating kinase assembly factor MAT1/Tfb3
IPR016818 Family Nitric oxide synthase-interacting
IPR017066 Family E3 ubiquitin-protein ligase BOI
IPR011364 Family Breast cancer type 1 susceptibility protein (BRCA1)
IPR004580 Family DNA repair protein, Rad18
IPR012227 Family TNF receptor-associated factor TRAF
IPR017335 Family E3 ubiquitin-protein ligase RNF8
IPR016398 Family E3 ubiquitin-protein ligase p28
IPR016495 Family p53 negative regulator Mdm2/Mdm4
IPR016569 Family Methyltransferase, trithorax
IPR015458 Family MDM4
IPR015459 Family Ubiquitin-protein ligase E3 MDM2
IPR001237 Family 43kDa postsynaptic protein
IPR007954 Family Baculovirus immediate-early

2 GO Annotations

GO Term Gene Name
GO:0005515 IPR001841
GO:0008270 IPR001841

2 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR001841
GO:0008270 IPR001841

1 Parent Features

DB identifier Type Name
IPR013083 Domain Zinc finger, RING/FYVE/PHD-type

172666 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
12113 D8RF45 PAC:15403022 Selaginella moellendorffii 397  
231449 D8RFV1 PAC:15416766 Selaginella moellendorffii 346  
440912 D8RFB4 PAC:15408654 Selaginella moellendorffii 2355  
8109 D8RFA0 PAC:15402722 Selaginella moellendorffii 73  
171333 D8RGE3 PAC:15408036 Selaginella moellendorffii 646  
38830 D8RHT0 PAC:15418121 Selaginella moellendorffii 67  
229713 D8TAW6 PAC:15412865 Selaginella moellendorffii 516  
430936 D8TB05 PAC:15401534 Selaginella moellendorffii 214  
39820 D8RIK2 PAC:15420975 Selaginella moellendorffii 55  
441252 D8RHZ8 PAC:15406340 Selaginella moellendorffii 2376  
93997 D8RI15 PAC:15402887 Selaginella moellendorffii 337  
137213 D8TD89 PAC:15418424 Selaginella moellendorffii 132  
172324 D8RKY2 PAC:15411137 Selaginella moellendorffii 264  
148275 D8RLF7 PAC:15406326 Selaginella moellendorffii 399  
39821 D8RM08 PAC:15420976 Selaginella moellendorffii 51  
39816 D8RM24 PAC:15420960 Selaginella moellendorffii 55  
39284 D8RM19 PAC:15416525 Selaginella moellendorffii 56  
412609 D8RM20 PAC:15413015 Selaginella moellendorffii 223  
412612 D8RM23 PAC:15413039 Selaginella moellendorffii 1011  
412607 D8RM16 PAC:15413012 Selaginella moellendorffii 392  
412606 D8RM15 PAC:15413010 Selaginella moellendorffii 138  
441660 D8RLS6 PAC:15409448 Selaginella moellendorffii 590  
441685 D8RM21 PAC:15409506 Selaginella moellendorffii 275  
8844 D8RLI6 PAC:15408158 Selaginella moellendorffii 62  
96681 D8RM17 PAC:15409405 Selaginella moellendorffii 150  
96631 D8RLP9 PAC:15409293 Selaginella moellendorffii 62  
97410 D8RMB3 PAC:15410678 Selaginella moellendorffii 978  
97849 D8RML3 PAC:15413878 Selaginella moellendorffii 311  
270336 D8QVX8 PAC:15419504 Selaginella moellendorffii 338  
37693 D8QV53 PAC:15413942 Selaginella moellendorffii 140  

13 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12665246
            15718139
            17210253
            15963892
            10529348
            11179890
            8804826
            8317827
            8744354
            10662664
            10577187
            10514377
            12944364