Protein Domain : IPR016569

Type:  Family Name:  Methyltransferase, trithorax
Description:  Members of this family encode proteins with methylase activity. The enzyme activity has been mapped to the SET domain [], originally identified in Drosophila melanogaster(Fruit fly) Su(var)3-9, E(z) and Trithorax proteins [].The mixed lineage leukemia (MLL) gene encodes a very large nuclear protein homologous to Drosophila trithorax (Trx). MLL is required for the proper maintenance of HOX gene expression during development and hematopoiesis []. The Trithorax group of proteins has been implicated in a variety of processes, including centromeric and telomeric silencing and cell-cycle regulation []. The sequence conservation pattern and structural analysis of the SET domain provides clues regarding possible active site residues. There are three conserved sequence motifs in most of the SET domain, two of which had been reported earlier. The N-terminal motif (I) has characteristic glycines. The central motif (II) has a distinct pattern of polar and charged residues (Asn, His). The C-terminal motif (III) has a characteristic dyad of polar residues and the hydrophobic residue tyrosine. Short Name:  MeTrfase_trithorax
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0 Child Features

7 Contains

DB identifier Type Name
IPR001214 Domain SET domain
IPR001841 Domain Zinc finger, RING-type
IPR001965 Domain Zinc finger, PHD-type
IPR003616 Domain Post-SET domain
IPR003888 Domain FY-rich, N-terminal
IPR001628 Domain Zinc finger, nuclear hormone receptor-type
IPR002857 Domain Zinc finger, CXXC-type

1 Cross References

Identifier
PIRSF010354

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0008270 IPR016569
GO:0042800 IPR016569
GO:0006355 IPR016569
GO:0051568 IPR016569
GO:0035097 IPR016569

5 Ontology Annotations

GO Term Gene Name
GO:0008270 IPR016569
GO:0042800 IPR016569
GO:0006355 IPR016569
GO:0051568 IPR016569
GO:0035097 IPR016569

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12039029
            12699618
            12447353
            15779005