Protein Domain : IPR001628

Type:  Domain Name:  Zinc finger, nuclear hormone receptor-type
Description:  Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences, connected via a linker region to a C-terminal ligand-binding domain (). In addition, certain nuclear hormone receptors have an N-terminal modulatory domain (). The DNA-binding domain can elicit either an activating or repressing effect by binding to specific regions of the DNA known as hormone-response elements [, ]. These response elements position the receptors, and the complexes recruited by them, close to the genes of which transcription is affected. The DNA-binding domains of nuclear receptors consist of two zinc-nucleated modules and a C-terminal extension, where residues in the first zinc module determine the specificity of the DNA recognition and residues in the second zinc module are involved in dimerisation. The DNA-binding domain is furthermore involved in several other functions including nuclear localisation, and interaction with transcription factors and co-activators [].Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents the two C4-type zinc finger modules involved in DNA-binding. Short Name:  Znf_hrmn_rcpt
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0 Child Features

0 Contains

5 Cross Referencess

Identifier
PF00105
PR00047
PS00031
PS51030
SM00399

12 Found Ins

DB identifier Type Name
IPR003072 Family Orphan nuclear receptor, NOR1 type
IPR003071 Family Orphan nuclear receptor, HMR type
IPR003073 Family Orphan nuclear receptor, NURR type
IPR016355 Family Nuclear hormone receptor family 5
IPR016569 Family Methyltransferase, trithorax
IPR001728 Family Thyroid hormone receptor
IPR003069 Family Ecdysteroid receptor
IPR003070 Family Orphan nuclear receptor
IPR003075 Family Peroxisome proliferator-activated receptor, beta
IPR003076 Family Peroxisome proliferator-activated receptor, alpha
IPR003077 Family Peroxisome proliferator-activated receptor, gamma
IPR003078 Family Retinoic acid receptor

5 GO Annotations

GO Term Gene Name
GO:0003700 IPR001628
GO:0008270 IPR001628
GO:0043565 IPR001628
GO:0006355 IPR001628
GO:0005634 IPR001628

5 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR001628
GO:0008270 IPR001628
GO:0043565 IPR001628
GO:0006355 IPR001628
GO:0005634 IPR001628

1 Parent Features

DB identifier Type Name
IPR013088 Domain Zinc finger, NHR/GATA-type

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Gorai.004G195700.1 A0A0D2R0T4 PAC:26772487 Gossypium raimondii 695  
Gomus.D08G204700.1.p A0A5D2TXY4 PAC:42044215 Gossypium mustelinum 695  
Gotom.A08G196000.1.p A0A5D2PHU5 PAC:42158320 Gossypium tomentosum 569  
Gotom.D08G211000.1.p A0A5D2K010 PAC:42198609 Gossypium tomentosum 600  
Gobar.D08G202900.1.p A0A5J5QIH4 PAC:42317398 Gossypium barbadense 695  
Godar.D08G215100.1.p A0A5D2BLX8 PAC:42526861 Gossypium darwinii 695  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12665246
            15718139
            17210253
            15963892
            10529348
            11179890
            15242341
            15242339