Protein Domain : IPR020061

Type:  Domain Name:  Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.Glutamate-tRNA ligase (also known as glutamyl-tRNA synthetase)() is a class Ic ligase and shows several similarities with glutamate-tRNA ligase concerning structure and catalytic properties. It is an alpha2 dimer. To date one crystal structure of a glutamate-tRNA ligase (Thermus thermophilus) has been solved. The molecule has the form of a bent cylinder and consists of four domains. The N-terminal half (domains 1 and 2) contains the 'Rossman fold' typical for class I ligases and resembles the corresponding part of Escherichia coliGlnRS, whereas the C-terminal half exhibits a GluRS-specific structure []. Short Name:  Glu/Gln-tRNA-synth_Ib_a-bdl
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0 Child Features

0 Contains

1 Cross References

Identifier
G3DSA:1.10.1160.10

5 Found Ins

DB identifier Type Name
IPR004526 Family Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
IPR020058 Domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR004527 Family Glutamate-tRNA ligase, bacterial/mitochondrial
IPR000924 Family Glutamyl/glutaminyl-tRNA synthetase
IPR004514 Family Glutamine-tRNA synthetase

5 GO Annotations

GO Term Gene Name
GO:0000166 IPR020061
GO:0004812 IPR020061
GO:0005524 IPR020061
GO:0006418 IPR020061
GO:0005737 IPR020061

5 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR020061
GO:0004812 IPR020061
GO:0005524 IPR020061
GO:0006418 IPR020061
GO:0005737 IPR020061

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cucsa.099920.8 PAC:16958495 Cucumis sativus 452  
AT2G30660.1 Q6NMB0 PAC:19639659 Arabidopsis thaliana 378  
Potri.009G169700.2 PAC:26986263 Populus trichocarpa 453  
Potri.009G169700.3 PAC:26986264 Populus trichocarpa 421  
Potri.013G041100.1 PAC:26995453 Populus trichocarpa 217  
Gorai.002G014600.4 A0A0D2QYQ4 PAC:26793821 Gossypium raimondii 509  
Gorai.002G014600.5 A0A0D2Q6F4 PAC:26793822 Gossypium raimondii 399  
Gorai.002G014600.6 A0A0D2M5D3 PAC:26793823 Gossypium raimondii 360  
Migut.B00003.2.p A0A022RCI0 PAC:28947553 Mimulus guttatus 428  
Glyma.03G097900.2.p I1JME8 PAC:30519132 Glycine max 405  
Medtr4g011570.1 A0A072UG65 PAC:31113468 Medicago truncatula 873  
evm_27.model.AmTr_v1.0_scaffold00044.240 U5CVB3 PAC:31575502 Amborella trichopoda 83  
evm_27.model.AmTr_v1.0_scaffold00071.123 U5D2Y4 PAC:31561198 Amborella trichopoda 492  
Traes_3B_0490784C0.3 PAC:31918974 Triticum aestivum 453  
Traes_6BS_821BE4320.3 PAC:31805464 Triticum aestivum 401  
Traes_7BL_8B42502D3.1 PAC:31915300 Triticum aestivum 615  
Traes_7BL_8B42502D3.2 PAC:31915301 Triticum aestivum 492  
Traes_7BL_8B42502D3.4 PAC:31915303 Triticum aestivum 262  
Traes_7BL_8B42502D3.5 PAC:31915304 Triticum aestivum 257  
Prupe.5G020600.1.p A0A251P2D0 PAC:32095966 Prunus persica 405  
Pahal.F02949.1 PAC:32485135 Panicum hallii 117  
Kalax.0920s0001.2.p PAC:32573644 Kalanchoe laxiflora 469  
Sphfalx0201s0018.1.p PAC:32621939 Sphagnum fallax 375  
Pp3s32_300V3.1.p PAC:32948399 Physcomitrium patens 593  
Pp3c1_19680V3.3.p PAC:32969295 Physcomitrium patens 586  
Pp3c2_37890V3.1.p A0A2K1L4K3 PAC:32937332 Physcomitrium patens 194  
Pp3c12_8260V3.2.p A9SLR8 PAC:32974702 Physcomitrium patens 68  
Pp3c12_8260V3.1.p A0A2K1JPW8 PAC:32974701 Physcomitrium patens 76  
Mapoly0003s0314.1.p A0A2R6XTP7 PAC:33009846 Marchantia polymorpha 109  
Aqcoe7G391700.1.p A0A2G5DGY3 PAC:33074483 Aquilegia coerulea 206  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            9426192
            10673435
            2203971