Protein Domain : IPR018486

Type:  Conserved_site Name:  Hemopexin, conserved site
Description:  Hemopexin () is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation []. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents []. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).This entry represents a conserved sequence region located at the beginning of the second repeat in the hemopexin domain. Short Name:  Hemopexin_CS

0 Child Features

0 Contains

1 Cross References

Identifier
PS00024

3 Found Ins

DB identifier Type Name
IPR021190 Family Peptidase M10A
IPR016293 Family Peptidase M10A, stromelysin-type
IPR000585 Domain Hemopexin-like domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14619953
            9572850
            12042069