Protein Domain : IPR016293

Type:  Family Name:  Peptidase M10A, stromelysin-type
Description:  This entry represents a subgroup of metazoan peptidases M10A, represented by stromelysin.The MEROPS peptidase family M10, subfamily M10A, consists of extracellular metalloproteases, such as collagenase and stromelysin, that degrade the extracellular matrix and are known as matrixins or matrix metalloproteinases (MMPs). They are zinc-dependent, calcium-activated proteases synthesised as inactive precursors(zymogens), which are proteolytically cleaved to yield the active enzyme [, ].All matrixins and related proteins possess two domains: an N-terminal domain, and a zinc-binding active site domain. The N-terminal domainpeptide, cleaved during the activation step, includes a conserved PRCGVPDV octapeptide, known as the cysteine switch, whose Cys residue chelates theactive site zinc atom, rendering the enzyme inactive [, ]. The active enzyme degrades components of the extracellular matrix, playing a role in the initial steps of tissue remodelling during morphogenesis, wound healing, angiogenesis and tumour invasion [, ]. Although it was initially thought that the primary function of these enzymes is to degrade proteins of the extracellular matrix, MMPs have a much broader spectrum of activity that includes the proteolytic processing of cytokines, growth factors, growth factor receptors, and cell adhesion molecules [, ]. Short Name:  Pept_M10A_stromelysin-type
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15 Child Features

DB identifier Type Name
IPR028693 Family Matrix metalloproteinase-14
IPR028697 Family Matrix metalloproteinase-16
IPR028700 Family Stromelysin 1
IPR028705 Family Stromelysin-3
IPR028709 Family Neutrophil collagenase
IPR028711 Family Collagenase 3
IPR028716 Family Matrix metalloproteinase-20
IPR028718 Family Macrophage metalloelastase
IPR028723 Family Matrix metalloproteinase-24
IPR028724 Family Matrix metalloproteinase-19
IPR028726 Family Matrix metalloproteinase-17
IPR028729 Family Matrix metalloproteinase-15
IPR028732 Family Matrix metalloproteinase-27
IPR028733 Family Matrix metalloproteinase-25
IPR028735 Family Matrix metalloproteinase-28

7 Contains

DB identifier Type Name
IPR002477 Domain Peptidoglycan binding-like
IPR006026 Domain Peptidase, metallopeptidase
IPR001818 Domain Peptidase M10, metallopeptidase
IPR000585 Domain Hemopexin-like domain
IPR018487 Repeat Hemopexin-like repeats
IPR018486 Conserved_site Hemopexin, conserved site
IPR021158 Binding_site Peptidase M10A, cysteine switch, zinc binding site

1 Cross References

Identifier
PIRSF001191

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004222 IPR016293
GO:0005509 IPR016293
GO:0008270 IPR016293
GO:0006508 IPR016293

4 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR016293
GO:0005509 IPR016293
GO:0008270 IPR016293
GO:0006508 IPR016293

1 Parent Features

DB identifier Type Name
IPR021190 Family Peptidase M10A

239 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
29822.m003413 B9RUG6 PAC:16809783 Ricinus communis 311  
29822.m003414 B9RUG7 PAC:16809784 Ricinus communis 321  
Cucsa.158750.1 A0A0A0KS39 PAC:16965168 Cucumis sativus 319  
Cucsa.158810.1 A0A0A0KVC8 PAC:16965174 Cucumis sativus 303  
orange1.1g021444m A0A067GSD7 PAC:18102852 Citrus sinensis 312  
Lus10032175 PAC:23161251 Linum usitatissimum 304  
Lus10035221 PAC:23162385 Linum usitatissimum 303  
Lus10014512 PAC:23170898 Linum usitatissimum 303  
Potri.008G027600.1 A0A2K1ZAQ7 PAC:27038133 Populus trichocarpa 308  
Potri.008G027500.1 A0A2K1ZAP3 PAC:27037650 Populus trichocarpa 317  
Potri.013G100400.1 A0A2K1Y3Q0 PAC:26994390 Populus trichocarpa 304  
Potri.019G073700.1 U5FG59 PAC:27026328 Populus trichocarpa 308  
Potri.019G073400.1 B9IQA6 PAC:27026482 Populus trichocarpa 308  
Potri.019G073800.1 A0A2K1WR14 PAC:27026206 Populus trichocarpa 308  
Potri.019G073500.1 A9PEJ3 PAC:27025262 Populus trichocarpa 309  
Gorai.001G258900.1 A0A0D2PWZ0 PAC:26823345 Gossypium raimondii 307  
Thecc1EG044196t1 PAC:27441709 Theobroma cacao 311  
Thecc1EG044201t1 A0A061FPL5 PAC:27441882 Theobroma cacao 311  
Thecc1EG046068t1 PAC:27437526 Theobroma cacao 311  
Thecc1EG040549t1 A0A061GRS4 PAC:27429464 Theobroma cacao 310  
Migut.K01350.1.p PAC:28936726 Mimulus guttatus 310  
Migut.K01352.1.p PAC:28937224 Mimulus guttatus 312  
Migut.K01351.1.p PAC:28937645 Mimulus guttatus 311  
Migut.K01354.1.p A0A022R398 PAC:28938135 Mimulus guttatus 312  
Migut.K01353.1.p PAC:28936801 Mimulus guttatus 312  
Migut.N02351.1.p A0A022R6Q1 PAC:28923044 Mimulus guttatus 304  
SapurV1A.2173s0010.1.p PAC:31442974 Salix purpurea 308  
SapurV1A.2193s0030.1.p PAC:31449864 Salix purpurea 312  
SapurV1A.2193s0040.1.p PAC:31449863 Salix purpurea 312  
SapurV1A.2501s0010.1.p PAC:31455761 Salix purpurea 308  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2167841
            2841336
            2551898
            1988438
            11544020
            19800373