Protein Domain : IPR028718

Type:  Family Name:  Macrophage metalloelastase
Description:  Macrophage metalloelastase (also known as matrix metalloproteinase-12, MMP12) was first identified as a secreted protein from mouse peritoneal macrophages through its elastase activity []. It shares many features with typical members of the matrix metalloproteinase (MMP) family including its domain structure and its ability to degrade the extracellular matrix components []. MMP12 regulates fibrosis in several models of tissue injury and has a protective effect on corneal fibrosis during wound repair through regulation of immune cell infiltration and angiogenesis []. Short Name:  MMP12
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10201:SF32

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004222 IPR028718
GO:0008270 IPR028718
GO:0006508 IPR028718
GO:0042060 IPR028718

4 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR028718
GO:0008270 IPR028718
GO:0006508 IPR028718
GO:0042060 IPR028718

1 Parent Features

DB identifier Type Name
IPR016293 Family Peptidase M10A, stromelysin-type

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            167096
            23813962