Protein Domain : IPR006026

Type:  Domain Name:  Peptidase, metallopeptidase
Description:  Metalloproteases are the most diverse of the four main types of protease, with more than 50 families identified to date. In these enzymes, a divalent cation, usually zinc, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. The known metal ligands are His, Glu, Asp or Lys and at least one other residue is required for catalysis, which may play an electrophillic role. Of the known metalloproteases, around half contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [].The majority of zinc-dependent metallopeptidases (with the notable exception of the carboxypeptidases) share a common pattern of primary structure [, ] in the part of their sequence involved in the binding of zinc, and can begrouped together as a superfamily,known as the metzincins, on the basis of this sequence similarity. They can be classified into around 40 distinct families []. This signature defines the metallopeptidases associated with MEROPS peptidase families: M7, M8, M10 (subfamilies A, B and C) and M12 (subfamily A) all of which are members of clan MA(M). Short Name:  Peptidase_Metallo
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2 Child Features

DB identifier Type Name
IPR001818 Domain Peptidase M10, metallopeptidase
IPR001506 Domain Peptidase M12A, astacin

0 Contains

1 Cross References

Identifier
SM00235

12 Found Ins

DB identifier Type Name
IPR021190 Family Peptidase M10A
IPR016293 Family Peptidase M10A, stromelysin-type
IPR016294 Family Peptidase M10B
IPR008294 Family Meprin alpha/beta subunit
IPR015446 Family Bone morphogenetic protein 1/tolloid-like protein
IPR017369 Family SPAN protein/blastula protease 10
IPR017050 Family Metallopeptidase, nematode
IPR017370 Family Hatching enzyme, Uvs2
IPR022603 Domain Domain of unknown function DUF3152
IPR017367 Family Peptidase M12A, nematode astacin 7/8, Caenorhabditis
IPR017368 Family Peptidase M12A, nematode astacin 9/10/11
IPR001843 Family Fragilysin

3 GO Annotations

GO Term Gene Name
GO:0008237 IPR006026
GO:0008270 IPR006026
GO:0006508 IPR006026

3 Ontology Annotations

GO Term Gene Name
GO:0008237 IPR006026
GO:0008270 IPR006026
GO:0006508 IPR006026

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
13930 D8RFP7 PAC:15412210 Selaginella moellendorffii 301  
110370 D8S744 PAC:15406730 Selaginella moellendorffii 361  
evm.model.supercontig_29.169 PAC:16416198 Carica papaya 368  
evm.model.supercontig_5.334 PAC:16421456 Carica papaya 357  
29736.m002110 B9S2J2 PAC:16807215 Ricinus communis 364  
29822.m003413 B9RUG6 PAC:16809783 Ricinus communis 311  
29822.m003414 B9RUG7 PAC:16809784 Ricinus communis 321  
30174.m008806 B9RD50 PAC:16822451 Ricinus communis 363  
27428.m000110 B9T6S0 PAC:16798283 Ricinus communis 226  
28619.m000044 B9T8P6 PAC:16801278 Ricinus communis 325  
Cucsa.330820.1 PAC:16978216 Cucumis sativus 292  
Cucsa.011110.1 PAC:16951372 Cucumis sativus 295  
Cucsa.158720.1 PAC:16965165 Cucumis sativus 295  
Cucsa.158820.1 PAC:16965175 Cucumis sativus 295  
Cucsa.158710.1 A0A0A0KS47 PAC:16965164 Cucumis sativus 313  
Cucsa.158730.1 PAC:16965166 Cucumis sativus 293  
Cucsa.158740.1 A0A0A0KU08 PAC:16965167 Cucumis sativus 316  
Cucsa.158750.1 A0A0A0KS39 PAC:16965168 Cucumis sativus 319  
Cucsa.158760.1 PAC:16965169 Cucumis sativus 291  
Cucsa.158770.1 PAC:16965170 Cucumis sativus 267  
Cucsa.158780.1 PAC:16965171 Cucumis sativus 292  
Cucsa.158790.1 PAC:16965172 Cucumis sativus 255  
Cucsa.158800.1 PAC:16965173 Cucumis sativus 264  
Cucsa.158810.1 A0A0A0KVC8 PAC:16965174 Cucumis sativus 303  
Cucsa.356580.1 PAC:16980318 Cucumis sativus 291  
Cucsa.356590.1 PAC:16980319 Cucumis sativus 185  
Cucsa.259810.1 PAC:16973078 Cucumis sativus 252  
Cucsa.275230.1 A0A0A0KRY9 PAC:16973958 Cucumis sativus 366  
Cucsa.301780.1 A0A0A0KRA5 PAC:16975655 Cucumis sativus 370  
orange1.1g035681m A0A067DG72 PAC:18130319 Citrus sinensis 320  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7674922
            2914602
            1894005