Protein Domain : IPR016294

Type:  Family Name:  Peptidase M10B
Description:  Metalloproteases are the most diverse of the four main types of protease, with more than 50 families identified to date. In these enzymes, a divalent cation, usually zinc, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. The known metal ligands are His, Glu, Asp or Lys and at least one other residue is required for catalysis, which may play an electrophillic role. Of the known metalloproteases, around half contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [].Proteins in this entry are metalloendopeptidases belong to the MEROPS peptidase family M10 (subfamily M10B, clan MA). They include serralysin, epralysin, mirabilysin, aeruginolysin and other related peptidases. The peptidase unit is found at the N terminus while in this entry it is found at the C terminus and forms a corkscrew. It is thought to be important for secretion of the protein through the bacterial cell wall. Proteins in this entry contain a calcium ion binding domain. Short Name:  Pept_M10B
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0 Child Features

6 Contains

DB identifier Type Name
IPR006026 Domain Peptidase, metallopeptidase
IPR001818 Domain Peptidase M10, metallopeptidase
IPR011049 Domain Serralysin-like metalloprotease, C-terminal
IPR013858 Domain Peptidase M10 serralysin, C-terminal
IPR001343 Repeat Haemolysin-type calcium-binding repeat
IPR018511 Conserved_site Hemolysin-type calcium-binding conserved site

1 Cross References

Identifier
PIRSF001205

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004222 IPR016294
GO:0005509 IPR016294
GO:0008270 IPR016294
GO:0006508 IPR016294
GO:0005615 IPR016294

5 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR016294
GO:0005509 IPR016294
GO:0008270 IPR016294
GO:0006508 IPR016294
GO:0005615 IPR016294

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7674922