Protein Domain : IPR028729

Type:  Family Name:  Matrix metalloproteinase-15
Description:  Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that cleave within a polypeptide (endopeptidases). They degrade most components of the extracellular matrix (such as growth factors, their binding proteins, and other bioactive molecules, as well as binding sites for cell-surface molecules) and some non-extracellular-matrix molecules []. Two categories of MMPs can be recognised based on their cellular localisation: soluble vs. membrane-bound. The soluble MMPs are divided into the collagenases (MMP1, MMP8 and MMP13), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP12) and those yet to be classified. The membrane-bound MMPs include MT1, 2, 3, 4, 5 and their hallmark is the presence of plasma membrane anchoring domains []. MMPs are highly expressed in various cancers, both by tumour cells and in surrounding stromal cells such as macrophages []. Matrix metalloproteinase-15 (MMP15) or membrane-type matrix metalloproteinase 2 degrades various components of the extracellular matrix [, ]. The increase expression of MMP15 has been linked to cancer progression []. Short Name:  MMP15
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10201:SF25

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004222 IPR028729
GO:0008270 IPR028729
GO:0006508 IPR028729
GO:0005887 IPR028729

4 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR028729
GO:0008270 IPR028729
GO:0006508 IPR028729
GO:0005887 IPR028729

1 Parent Features

DB identifier Type Name
IPR016293 Family Peptidase M10A, stromelysin-type

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12027585
            12801404
            9461298
            7559440
            22998427