Protein Domain : IPR006468

Type:  Family Name:  Nitrate reductase, alpha subunit
Description:  The nitrate reductase enzyme complex allows bacteria to use nitrate as an electron acceptor during anaerobic growth. The enzyme complex is a heterotrimer consisting of alpha, beta and gamma subunits []. The alpha subunit contains a molybdenum cofactor, the beta subunit contains [Fe-S]clusters while the gamma subunit contains haem and is membrane bound. The alpha and beta subunits form a membrane extrinsic catalytic dimer which is bound to the membrane by the gamma subunit, which is a b-type cytochrome that receives electrons from the quinone pool and transfers them to the beta subunit. The three subunits form a stable "flower"-shaped structure [], where the gamma subunit anchors the alpha and beta subunits to the membrane through predominantly hydrophobic interactions. The structure is further stabilised by the presence of a phosphatidylglycerol molecule that is bound by all three subunits. The alpha subunit uses a Mo-bisMGD cofactor for catalytic activity and, like other proteins that bind this cofactor, forms four alpha-beta domains grouped around the cofactor. Interaction with the other catalytic subunit occurs along an extensive, buried interface. Short Name:  NarG
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0 Child Features

3 Contains

DB identifier Type Name
IPR006656 Domain Molybdopterin oxidoreductase
IPR006657 Domain Molybdopterin dinucleotide-binding domain
IPR006655 Conserved_site Molybdopterin oxidoreductase, prokaryotic, conserved site

1 Cross References

Identifier
TIGR01580

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008940 IPR006468
GO:0042126 IPR006468
GO:0055114 IPR006468
GO:0009325 IPR006468

4 Ontology Annotations

GO Term Gene Name
GO:0008940 IPR006468
GO:0042126 IPR006468
GO:0055114 IPR006468
GO:0009325 IPR006468

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11289300
            12910261