Protein Domain : IPR006655

Type:  Conserved_site Name:  Molybdopterin oxidoreductase, prokaryotic, conserved site
Description:  A number of different prokaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown [, , ] to share a number of regions of sequence similarity. These enzymes are:Escherichia coli respiratory nitrate reductase (EC 1.7.99.4). This enzyme complex allows the bacteria to use nitrate as an electron acceptor duringanaerobic growth. The enzyme is composed of three different chains: alpha, beta and gamma. The alpha chain (gene narG) is the molybdopterin-bindingsubunit. Escherichia coli encodes for a second, closely related, nitrate reductase complex which also contains a molybdopterin-binding alpha chain(gene narZ).Escherichia coli anaerobic dimethyl sulfoxide reductase (DMSO reductase). DMSO reductase is the terminal reductase during anaerobic growth on varioussulfoxide and N-oxide compounds. DMSO reductase is composed of three chains: A, B and C. The A chain (gene dmsA) binds molybdopterin.Escherichia coli biotin sulfoxide reductases (genes bisC and bisZ). This enzyme reduces a spontaneous oxidation product of biotin, BDS, back tobiotin. It may serve as a scavenger, allowing the cell to use biotin sulfoxide as a biotin source.Methanobacterium formicicum formate dehydrogenase (EC 1.2.1.2). The alpha chain (gene fdhA) of this dimeric enzyme binds a molybdopterin cofactor.Escherichia coli formate dehydrogenases -H (gene fdhF), -N (gene fdnG) and -O (gene fdoG). These enzymes are responsible for the oxidation of formateto carbon dioxide. In addition to molybdopterin, the alpha (catalytic) subunit also contains an active site, selenocysteine.Wolinella succinogenes polysulfide reductase chain. This enzyme is a component of the phosphorylative electron transport system with polysulfideas the terminal acceptor. It is composed of three chains: A, B and C. The A chain (gene psrA) binds molybdopterin.Salmonella typhimurium thiosulfate reductase (gene phsA). - Escherichia coli trimethylamine-N-oxide reductase (EC 1.6.6.9) (gene torA)[].Nitrate reductase (EC 1.7.99.4) from Klebsiella pneumoniae (gene nasA), Alcaligenes eutrophus, Escherichia coli, Rhodobacter sphaeroides,Thiosphaera pantotropha (gene napA), and Synechococcus PCC 7942 (gene narB).These proteins range from 715 amino acids (fdhF) to 1246 amino acids (narZ) in size.This entry represents a conserved region located in these enzymes. Short Name:  Mopterin_OxRdtase_prok_CS
Paste the following link

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PS00490
PS00932

8 Found Ins

DB identifier Type Name
IPR006963 Domain Molybdopterin oxidoreductase, 4Fe-4S domain
IPR006656 Domain Molybdopterin oxidoreductase
IPR006478 Family Formate dehydrogenase, alpha subunit
IPR006468 Family Nitrate reductase, alpha subunit
IPR006443 Family Formate dehydrogenase-N, alpha subunit
IPR006658 Family Molybdopterin guanine dinucleotide-containing S/N-oxide reductase
IPR011888 Family Anaerobic dimethyl sulphoxide reductase, subunit A, DmsA/YnfE
IPR010051 Family Periplasmic nitrate reductase, large subunit

3 GO Annotations

GO Term Gene Name
GO:0009055 IPR006655
GO:0016491 IPR006655
GO:0055114 IPR006655

3 Ontology Annotations

GO Term Gene Name
GO:0009055 IPR006655
GO:0016491 IPR006655
GO:0055114 IPR006655

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2015248
            8125918
            3062312
            8022286