Protein Domain : IPR006443

Type:  Family Name:  Formate dehydrogenase-N, alpha subunit
Description:  This family of sequences describe a subset of formate dehydrogenase alpha chains found mainly in proteobacteria but also in Aquifex aeolicus. The alpha chain contains domains for molybdopterin dinucleotide binding and molybdopterin oxidoreductase. The holo-enzyme also contains beta and gamma subunits of 32 and 20 kDa. The enzyme catalyzes the oxidation of formate (produced from pyruvate during anaerobic growth) to carbon dioxide with the concomitant release of two electrons and two protons. The electrons are utilised mainly in the nitrate respiration by nitrate reductase []. In Escherichia coliand Salmonella typhi, there are two forms of the formate dehydrogenase, one induced by nitrate which is strictly anaerobic (fdn), and one induced during the transition from aerobic to anaerobic growth (fdo). This subunit is one of only three proteins in E. coli which contains selenocysteine []. Short Name:  Formate-DH-alph_fdnG
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0 Child Features

5 Contains

DB identifier Type Name
IPR006963 Domain Molybdopterin oxidoreductase, 4Fe-4S domain
IPR006656 Domain Molybdopterin oxidoreductase
IPR006311 Conserved_site Twin-arginine translocation pathway, signal sequence
IPR006657 Domain Molybdopterin dinucleotide-binding domain
IPR006655 Conserved_site Molybdopterin oxidoreductase, prokaryotic, conserved site

1 Cross References

Identifier
TIGR01553

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0008863 IPR006443
GO:0009055 IPR006443
GO:0043546 IPR006443
GO:0047111 IPR006443
GO:0045333 IPR006443

5 Ontology Annotations

GO Term Gene Name
GO:0008863 IPR006443
GO:0009055 IPR006443
GO:0043546 IPR006443
GO:0047111 IPR006443
GO:0045333 IPR006443

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3045516
            1834669