Protein Domain : IPR016218

Type:  Family Name:  Acetyl-CoA decarbonylase/synthase complex, gamma subunit
Description:  This group represents the gamma subunit of acetyl-CoA decarbonylase/synthase (ACDS), a complex catalysing the reversible cleavage of acetyl-CoA. Depending on the direction of the reaction this complex allows either growth on acetate as sole carbon and energy source, or autotrophic growth from carbon dioxide/carbon monoxide [].The ACDS complex contains five subunits, among which beta possesses an Ni-Fe-S active-site metal cluster, the A-cluster, at which reaction with acetyl-CoA takes place, generating an acetyl-enzyme species poised for C-C bond cleavage []. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).Titration experiments indicate that two electrons are required for activation of the enzyme in the process of forming the enzyme-acetyl intermediate []. Short Name:  AcylCoA_decarb/synth_gsu

1 Child Features

DB identifier Type Name
IPR023427 Family Acetyl-CoA decarbonylase/synthase complex, gamma subunit, archaea

3 Contains

DB identifier Type Name
IPR011005 Domain Dihydropteroate synthase-like
IPR016041 Domain CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel
IPR007202 Domain 4Fe-4S domain

1 Cross References

Identifier
PIRSF000376

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005506 IPR016218
GO:0008168 IPR016218
GO:0046356 IPR016218

3 Ontology Annotations

GO Term Gene Name
GO:0005506 IPR016218
GO:0008168 IPR016218
GO:0046356 IPR016218

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14709073
            14664578
            18442256