Protein Domain : IPR011005

Type:  Domain Name:  Dihydropteroate synthase-like
Description:  All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. The enzyme 7,8-dihydropteroate synthase (DHPS) () catalyses the condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin-pyrophosphate to form 7,8-dihydropteroate and pyrophosphate. DHPS is essential for the de novo synthesis of folate in prokaryotes, lower eukaryotes, and in plants, but is absent in mammals []. By contrast, higher vertebrates possess an active transport system that enables them to use dietary folates. DHPS is the target of sulphonamides, which are substrate analogues that compete with pABA, but which do not affect vertebrates as they lack the DHPS enzyme. DHPS is a single domain protein that forms an eight-stranded TIM alpha/beta barrel, where the 7,8-dihydropterin pyrophosphate substrate binds in a deep cleft in the barrel []. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [].Other proteins contain a DHPS-like domain, including members of the methyltetrahydrofolate (corrinoid iron-sulphur protein methyltransferase (MeTr)) family. MeTr catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation []. Other members of this family that contain a DHPS-like domain include methionine synthase and methanogenic enzymes that activate the methyl group of methyltetrahydromethano(or -sarcino)pterin. Short Name:  Dihydropteroate_synth-like
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2 Child Features

DB identifier Type Name
IPR000489 Domain Pterin-binding domain
IPR016041 Domain CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel

0 Contains

1 Cross References

Identifier
SSF51717

10 Found Ins

DB identifier Type Name
IPR004588 Family 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type
IPR017178 Family 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical
IPR011822 Family Cobalamin-dependent methionine synthase
IPR016425 Family 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial
IPR016227 Family Dihydropteroate synthase, predicted
IPR016261 Family Folic acid synthesis protein FOL1
IPR016218 Family Acetyl-CoA decarbonylase/synthase complex, gamma subunit
IPR004486 Family CO dehydrogenase/acetyl-CoA synthase delta subunit
IPR017215 Family 5-methyltetrahydrofolate-homocysteine S-methyltransferase, bacterial
IPR005236 Family Dihydropteroate synthase-related protein synthase-related protein

1 GO Annotation

GO Term Gene Name
GO:0044237 IPR011005

1 Ontology Annotations

GO Term Gene Name
GO:0044237 IPR011005

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
149035 D8RQF1 PAC:15407541 Selaginella moellendorffii 690  
80180 D8QWP2 PAC:15403078 Selaginella moellendorffii 506  
evm.model.supercontig_1.153 PAC:16404070 Carica papaya 533  
evm.model.supercontig_216.13 PAC:16413764 Carica papaya 740  
29729.m002362 B9S4E5 PAC:16807011 Ricinus communis 487  
34384.m000015 B9TKY6 PAC:16826197 Ricinus communis 321  
28076.m000417 B9SWB7 PAC:16799874 Ricinus communis 716  
Cucsa.164830.2 PAC:16965915 Cucumis sativus 506  
Cucsa.164830.1 PAC:16965914 Cucumis sativus 511  
Cucsa.226910.1 A0A0A0LXJ8 PAC:16969997 Cucumis sativus 741  
Cucsa.226910.2 A0A0A0LXJ8 PAC:16969998 Cucumis sativus 741  
orange1.1g038230m A0A067FW01 PAC:18121533 Citrus sinensis 480  
orange1.1g004623m PAC:18097609 Citrus sinensis 741  
orange1.1g004629m PAC:18097610 Citrus sinensis 741  
orange1.1g006566m PAC:18097613 Citrus sinensis 640  
orange1.1g004634m PAC:18097605 Citrus sinensis 741  
orange1.1g004626m PAC:18097607 Citrus sinensis 741  
orange1.1g004620m PAC:18097608 Citrus sinensis 741  
orange1.1g005248m PAC:18097612 Citrus sinensis 706  
orange1.1g004621m PAC:18097606 Citrus sinensis 741  
AT4G30000.1 Q9SZV3 PAC:19644970 Arabidopsis thaliana 554  
AT4G30000.2 Q9SZV3 PAC:19644969 Arabidopsis thaliana 561  
AT1G69190.1 Q1ENB6 PAC:19654554 Arabidopsis thaliana 484  
Thhalv10024845m V4P448 PAC:20194881 Eutrema salsugineum 547  
Thhalv10019460m V4KET2 PAC:20191341 Eutrema salsugineum 480  
Ciclev10027950m V4UES6 PAC:20813289 Citrus clementina 676  
Ciclev10027884m V4SG76 PAC:20813288 Citrus clementina 741  
Ciclev10027881m V4SG76 PAC:20813287 Citrus clementina 741  
Ciclev10031259m V4TD06 PAC:20805137 Citrus clementina 514  
Ciclev10031261m V4TD06 PAC:20805139 Citrus clementina 514  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9187658
            10997901
            1313386
            11007651