| Type: | Family | Name: | CDK5 and ABL1 enzyme substrate 1/2 |
| Description: | This group represents protein CABLES (CDK5 and ABL1 enzyme substrate), including CABLES1 and CABLES2 [, ]. CABLES1 is a cyclin-dependent kinase binding protein, primarily involved in cell cycle regulation []. CABLES1 binds to different functional domains of p53 and p73 and modifies their cell death-inducing activities []. It may be a tumour suppressor in human ovarian cancer []. CABLES2 is involved in both p53-mediated and p53-independent apoptotic pathways []. | Short Name: | CABLES1/2 |
