| Type: | Domain | Name: | Cyclin, N-terminal |
| Description: | Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2(Herpesvirus saimiri) and Human herpesvirus 8(HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Cyclins contain two domains of similar all-alpha fold, of which this entry is associated with the N-terminal domain. | Short Name: | Cyclin_N |
| DB identifier | Type | Name |
|---|---|---|
| IPR013763 | Domain | Cyclin-like |
| IPR015429 | Family | Cyclin C/H/T/L |
| IPR012104 | Family | PHO85 cyclin 1/2/9 |
| IPR012388 | Family | CDK5 and ABL1 enzyme substrate 1/2 |
| IPR015451 | Family | Cyclin D |
| IPR012399 | Family | Cyclin Y |
| IPR015452 | Family | Cyclin B3, G2/mitotic-specific |
| IPR014399 | Family | Cyclin CLN |
| IPR015453 | Family | Cyclin A, chordates |
| IPR015430 | Family | Cyclin T |
| IPR015431 | Family | Cyclin L1, chordata |
| IPR017285 | Family | Cyclin, herpesvirus |
