Protein Domain : IPR006261

Type:  Family Name:  Deoxyguanosinetriphosphate triphosphohydrolase
Description:  Deoxyguanosine triphosphate triphosphohydrolase (dGTPase) releases inorganic triphosphate, an unusual reaction product, from GTP []. dGTPase preferentially hydrolyses dGTP over the other canonical NTPs []. It has been suggested that its activity is limited to the Enterobacteriaceae [], although homologous sequences are detected elsewhere []. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from Escherichia coliwas shown to bind cooperatively to single stranded DNA. Short Name:  dGTP_triP_hydro
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3 Child Features

DB identifier Type Name
IPR020779 Family Deoxyguanosinetriphosphate triphosphohydrolase, proteobacteria
IPR023023 Family Deoxyguanosinetriphosphate triphosphohydrolase, type 2
IPR023024 Family Deoxyguanosinetriphosphate triphosphohydrolase, type 3

2 Contains

DB identifier Type Name
IPR006674 Domain HD domain
IPR003607 Domain HD/PDEase domain

1 Cross References

Identifier
TIGR01353

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0000287 IPR006261
GO:0008832 IPR006261
GO:0046039 IPR006261

3 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR006261
GO:0008832 IPR006261
GO:0046039 IPR006261

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9422594
            13563461
            2826481
            1657865