Protein Domain : IPR002209

Type:  Family Name:  Fibroblast growth factor family
Description:  Fibroblast growth factors (FGFs) [, ] are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Short Name:  Fibroblast_GF_fam
Paste the following link

22 Child Features

DB identifier Type Name
IPR028296 Family Fibroblast growth factor 22
IPR028292 Family Fibroblast growth factor 21
IPR028285 Family Fibroblast growth factor 16
IPR028287 Family Fibroblast growth factor 17
IPR028284 Family Fibroblast growth factor 14
IPR028289 Family Fibroblast growth factor 18
IPR028291 Family Fibroblast growth factor 20
IPR028279 Family Fibroblast growth factor 13
IPR028304 Family Fibroblast growth factor 23
IPR028303 Family Fibroblast growth factor 15/19
IPR028210 Family Fibroblast growth factor 1
IPR028252 Family Fibroblast growth factor 10
IPR028253 Family Fibroblast growth factor 11
IPR028254 Family Fibroblast growth factor 12
IPR028251 Family Fibroblast growth factor 9
IPR028242 Family Fibroblast growth factor 6
IPR028240 Family Fibroblast growth factor 5
IPR028249 Family Fibroblast growth factor 8
IPR028247 Family Fibroblast growth factor 7
IPR028232 Family Fibroblast growth factor 3
IPR028239 Family Fibroblast growth factor 4
IPR028223 Family Fibroblast growth factor 2

0 Contains

4 Cross Referencess

Identifier
PTHR11486
PR00263
PS00247
SM00442

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0008083 IPR002209

1 Ontology Annotations

GO Term Gene Name
GO:0008083 IPR002209

1 Parent Features

DB identifier Type Name
IPR008996 Family Cytokine, IL-1-like

0 Proteins

16 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2549857
            7583099
            3072709
            11276432
            8652550
            1705486
            8760337
            23000357
            15689573
            10441498
            23108135
            23016864
            1649700
            11746231
            14745970
            8978613