3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005104 | IPR028210 |
| GO:0008543 | IPR028210 |
| GO:0005576 | IPR028210 |
| Type: | Family | Name: | Fibroblast growth factor 1 |
| Description: | Fibroblast growth factors (FGFs) [, ] are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily.This entry represents fibroblast growth factor 1 (FGF1), also known as heparin-binding growth factor 1 and acidic fibroblast growth factor. The protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, and is therefore thought to be involved in organogenesis [, , ]. In addition to interacting with FGFR1-4, FGF1 has also been shown to interact with casein kinase II subunits [], heat shock proteins [] and acidic fibroblast growth factor intracellular-binding protein []. | Short Name: | FGF1 |
| GO Term | Gene Name |
|---|---|
| GO:0005104 | IPR028210 |
| GO:0008543 | IPR028210 |
| GO:0005576 | IPR028210 |
