Protein Domain : IPR017948

Type:  Conserved_site Name:  Transforming growth factor beta, conserved site
Description:  Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein [].A number of proteins are known to be related to TGF-beta-1 [, ]. Proteins from the TGF-beta family are only active as homo- or heterodimer; the two chains being linked by a single disulphide bond. From X-ray studies of TGF-beta-2 [], it is known that all the other cysteines are involved in intrachain disulphide bonds. There are four disulphide bonds in the TGF-beta's and in inhibin beta chains, while the other members of this family lack the first bond.The regulatory cytokine TGF-beta exerts tumour-suppressive effects, but also modulates cell invasion and immune regulation []. Misregulation of the TGF-beta signalling pathway can result in tumour development. This entry represents a conserved region within the TGF-beta domain that includes two of the conserved cysteines. Short Name:  TGFb_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00250

17 Found Ins

DB identifier Type Name
IPR000381 Family Inhibin, beta B subunit
IPR021203 Family Muellerian-inhibiting factor
IPR016319 Family Transforming growth factor-beta
IPR003939 Family Transforming growth factor, beta 1
IPR003940 Family Transforming growth factor, beta 2
IPR015618 Family Transforming growth factor beta-3
IPR015615 Family Transforming growth factor-beta-related
IPR001839 Domain Transforming growth factor-beta, C-terminal
IPR002405 Family Inhibin, alpha subunit
IPR017175 Family Inhibin, alpha subunit subgroup
IPR015923 Family Bone morphogenetic protein 15
IPR000491 Family Inhibin, beta A subunit
IPR017197 Family Bone morphogenetic protein 3/3B
IPR015617 Family Growth differentiation factor-9
IPR001318 Family Inhibin, beta C subunit
IPR003942 Family Left- Right determination factor
IPR015616 Family Growth/differentiation factor 8

1 GO Annotation

GO Term Gene Name
GO:0008083 IPR017948

1 Ontology Annotations

GO Term Gene Name
GO:0008083 IPR017948

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1575734
            8199356
            1631557
            8679613
            18662538