Protein Domain : IPR016316

Type:  Family Name:  Thrombomodulin
Description:  Thrombomodulin is an endothelial cell thrombin receptor that converts thrombin from a procoagulant to an anticoagulant enzyme [, ]. Thrombomodulin forms a 1:1 stoichiometric complex with thrombin that is responsible for the conversion of protein C to the activated protein CA. Protein CA scissions the activated cofactors of the coagulation mechanism, factors VA and VIIIA, and thereby reduces the amount of thrombin generated. Short Name:  CD141
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0 Child Features

7 Contains

DB identifier Type Name
IPR001304 Domain C-type lectin
IPR000742 Domain EGF-like domain
IPR001881 Domain EGF-like calcium-binding domain
IPR013032 Conserved_site EGF-like, conserved site
IPR018097 Conserved_site EGF-like calcium-binding, conserved site
IPR000152 PTM EGF-type aspartate/asparagine hydroxylation site
IPR015149 Domain Thrombomodulin-like, EGF-like

1 Cross References

Identifier
PIRSF001775

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004888 IPR016316
GO:0030195 IPR016316
GO:0005887 IPR016316

3 Ontology Annotations

GO Term Gene Name
GO:0004888 IPR016316
GO:0030195 IPR016316
GO:0005887 IPR016316

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8216207
            2844823