Protein Domain : IPR015149

Type:  Domain Name:  Thrombomodulin-like, EGF-like
Description:  This domain adopts a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with thrombin, and subsequent activation of protein-C []. Short Name:  Tme5_EGF-like
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0 Child Features

1 Contains

DB identifier Type Name
IPR013032 Conserved_site EGF-like, conserved site

1 Cross References

Identifier
PF09064

1 Found In

DB identifier Type Name
IPR016316 Family Thrombomodulin

2 GO Annotations

GO Term Gene Name
GO:0004888 IPR015149
GO:0016021 IPR015149

2 Ontology Annotations

GO Term Gene Name
GO:0004888 IPR015149
GO:0016021 IPR015149

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10761923