Protein Domain : IPR006117

Type:  Conserved_site Name:  2-5-oligoadenylate synthetase, conserved site
Description:  2'-5'-oligoadenylate synthetases constitute a family of interferon-induced enzymes that bind double-stranded RNA (dsRNA) and polymerise ATP into 2'-5' linked oligomers of adenosine (pppA(2'p5'A)n) (2-5A) of various lengths. The 2-5A molecules activate a latent ribonuclease (Rnase L) that then cleaves single-stranded RNAs; as a result protein synthesis and virus growth are inhibited. Thus 2-5A synthetases play an important role in the antiviral action of interferons.Three distinct classes of 2-5A synthetases have been described that correspond to proteins of 40-46 Kd, 69-71 Kd, and 100 Kd. The 40 and 46 Kd forms are produced by alternative splicing of the same gene. The 69 and 71 Kd forms are also produced by alternative splicing of a gene and consist of two adjacent homologous domains whose sequences are highly similar to that of the 40/46 Kd forms. The sequence of the 100 Kd form is not yet known. This domain corresponds to a highly conserved region located in the C-terminal part of 2-5A synthetase proteins or domains. The proposed ATP-binding domain is described in . Short Name:  2-5-oligoadenylate_synth_CS
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PS00832
PS00833

2 Found Ins

DB identifier Type Name
IPR018952 Domain 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
IPR006116 Domain 2-5-oligoadenylate synthetase, N-terminal

4 GO Annotations

GO Term Gene Name
GO:0003723 IPR006117
GO:0005524 IPR006117
GO:0016740 IPR006117
GO:0006955 IPR006117

4 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR006117
GO:0005524 IPR006117
GO:0016740 IPR006117
GO:0006955 IPR006117

0 Parent Features

0 Proteins

0 Publications