1 Contains
| DB identifier | Type | Name |
|---|---|---|
| IPR006117 | Conserved_site | 2-5-oligoadenylate synthetase, conserved site |
| Type: | Domain | Name: | 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal |
| Description: | This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between residues 320 and 344 at the extreme C-terminal end []. Oligoadenylate synthetases are antiviral enzymes that counteract viral attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesise 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication []. This domain is often associated with . | Short Name: | 2-5-oligoAdlate_synth_1_dom2/C |
| DB identifier | Type | Name |
|---|---|---|
| IPR006117 | Conserved_site | 2-5-oligoadenylate synthetase, conserved site |
