3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0051225 | IPR026242 |
| GO:0051297 | IPR026242 |
| GO:0070652 | IPR026242 |
| Type: | Family | Name: | HAUS augmin-like complex subunit 2, metazoa |
| Description: | Assembly of a robust microtubule-based mitotic spindle is essential for accurate segregation of chromosomes to progeny. Spindle assembly relies on the concerted action of centrosomes, spindle microtubules, molecular motors and non-motor spindle proteins []. A number of novel regulators of spindle assembly have been identified: one of these is HAUS, an 8-subunit protein complex that shares similarity with Drosophila Augmin [, ].HAUS augmin-like complex subunit 2 is a component of the HAUS augmin-like complex, which localises to the centrosomes and interacts with the gamma-tubulin ring complex (gamma-TuRC) []. The interaction between augmin and gamm-TuRC is important for spindle microtubule generation and affects the mitotic progression and cytokinesis []. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis []. The HAUS (Homologous to AUgmin Subunits) individual subunits have been designated HAUS1 to HAUS8 []. The HAUS augmin-like complex subunit 2 was previously known as centrosomal protein of 27 kDa (Cep27). | Short Name: | HAUS2_metazoa |
| GO Term | Gene Name |
|---|---|
| GO:0051225 | IPR026242 |
| GO:0051297 | IPR026242 |
| GO:0070652 | IPR026242 |
