Protein Domain : IPR010515

Type:  Domain Name:  Collagenase NC10/endostatin
Description:  NC10 stands for Non-helical region 10 and is taken from . A mutation in this region in is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor []. Endostatin also binds a zinc ion near the N terminus; this is likely to be of structural rather than functional importance according to []. Short Name:  Collagenase_NC10/endostatin
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0 Child Features

0 Contains

1 Cross References

Identifier
PF06482

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005198 IPR010515
GO:0007155 IPR010515
GO:0031012 IPR010515

3 Ontology Annotations

GO Term Gene Name
GO:0005198 IPR010515
GO:0007155 IPR010515
GO:0031012 IPR010515

1 Parent Features

DB identifier Type Name
IPR016186 Domain C-type lectin-like

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11606364
            10704302