| Type: | Domain | Name: | C-type lectin-like |
| Description: | Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity [], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions []. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [].This entry represents a structural domain found in C-type lectins, as well as in other proteins, including:The C-terminal domain of invasin [] and intimin [].Link domain, which includes the Link module of TSG-6 [] (a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal beta-strand and C-terminal beta-hairpin) [].Endostatin [] and the endostatin domain of collagen alpha 1 (XV) [], these domains being decorated with many insertions in the common fold. | Short Name: | C-type_lectin-like |
