Protein Domain : IPR016212

Type:  Family Name:  Methyl coenzyme M reductase, alpha subunit
Description:  Methyl-coenzyme M reductase (MCR) catalyses the reduction of methyl-coenzyme M (CH3-SCoM) and coenzyme B (HS-CoB) to methane and the corresponding heterosulphide CoM-S-S-CoB (), the final step in methane biosynthesis. This reaction proceeds under anaerobic conditions by methanogenic Archaea [], and requires a nickel-porphinoid prosthetic group, coenzyme F430, which is in the EPR-detectable Ni(I) oxidation state in the active enzyme. Studies on a catalytically inactive enzyme aerobically co-crystallized with coenzyme M displayed a fully occupied coenzyme M-binding site with no alternate conformations. The binding of coenzyme M appears to induce specific conformational changes that suggests a molecular mechanism by which the enzyme ensures that methyl-coenzyme M enters the substrate channel prior to coenzyme B, as required by the active-site geometry [].MCR is a hexamer composed of 2 alpha, 2 beta, and 2 gamma subunits with two identical nickel porphinoid active sites, which form two long active site channels with F430 embedded at the bottom [, ]. This group represents the alpha subunit of methyl coenzyme M reductase, also called coenzyme-B sulfoethylthiotransferase (). This enzyme, with alpha, beta, and gamma subunits, catalyses the last step in methanogenesis. Several methanogens have encode two such enzymes, designated I and II; this model does not separate the isozymes. Short Name:  Me_CoM_Rdtase_asu
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0 Child Features

6 Contains

DB identifier Type Name
IPR015823 Domain Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2
IPR022681 Domain Methyl-coenzyme M reductase, alpha/beta subunit, domain 2, C-terminal
IPR015811 Domain Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1
IPR008924 Domain Methyl-coenzyme M reductase, alpha/beta subunit, C-terminal
IPR003183 Domain Methyl-coenzyme M reductase, alpha subunit, N-terminal
IPR009047 Domain Methyl-coenzyme M reductase, alpha subunit, C-terminal

2 Cross Referencess

Identifier
PIRSF000262
TIGR03256

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0050524 IPR016212
GO:0015948 IPR016212

2 Ontology Annotations

GO Term Gene Name
GO:0050524 IPR016212
GO:0015948 IPR016212

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9367957
            11491299
            16260307
            16234924