Protein Domain : IPR023061

Type:  Family Name:  Selenophosphate synthetase, class I
Description:  The UGA (TGA) codon is normally a termination codon, however it is also used as a selenocysteine (Sec) codon by numerous organisms []. Sec is the 21st amino acid that is inserted into selenoproteins (protein that includes a selenocysteine (Se-Cys) amino acid residue). The synthesis of Sec and its incorporation into proteins requires the activity of a number of proteins, one of which is selenophosphate synthetase (SPS), also known as the SelD gene product [, ]. SPS catalises the production of the selenium donor compound monoselenophosphate (MSP) from selenide and ATP. MSP is then used to synthesize Sec from seryl-tRNAs []. SPS was initially identified in E. coli as the product of the gene selD, one of four essential selenoprotein synthesis genes (selA-D) [, ]. SelC is the tRNA itself, SelD acts as a donor of reduced selenium, SelA modifies a serine residue on SelC into selenocysteine, and SelB is a selenocysteine-specific translation elongation factor. 3' or 5' non-coding elements of mRNA have been found as probable structures for directing selenocysteine incorporation. This entry represents the typeI SPS, mostly from bacteria. Short Name:  SelD_I

0 Child Features

0 Contains

1 Cross References

Identifier
MF_00625

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004756 IPR023061
GO:0005524 IPR023061
GO:0016260 IPR023061

3 Ontology Annotations

GO Term Gene Name
GO:0004756 IPR023061
GO:0005524 IPR023061
GO:0016260 IPR023061

1 Parent Features

DB identifier Type Name
IPR004536 Family Selenophosphate synthetase

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2142875
            8986768
            8811175
            2405383
            1557403