Protein Domain : IPR000040

Type:  Family Name:  Acute myeloid leukemia 1 protein (AML1)/Runt
Description:  The AML1 (also known as RUNX1) gene is rearranged by the t(8;21) translocation in acute myeloid leukemia []. The gene is highly similar to the Drosophila melanogastersegmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [].The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction. In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal regionrich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters. The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role in the development ofnormal hematopoiesis. CBF is a nuclear protein expressed in numerous tissue types, except brain and heart; highest levels have been found to occur in thymus, bone marrow and peripheral blood. Short Name:  AML1_Runt
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1 Child Features

DB identifier Type Name
IPR016554 Family Runt-related transcription factor RUNX

2 Contains

DB identifier Type Name
IPR013524 Domain Runt domain
IPR013711 Domain Runx, C-terminal domain

2 Cross Referencess

Identifier
PTHR11950
PR00967

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR000040
GO:0005524 IPR000040
GO:0006355 IPR000040
GO:0005634 IPR000040

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR000040
GO:0005524 IPR000040
GO:0006355 IPR000040
GO:0005634 IPR000040

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7651838