Protein Domain : IPR013524

Type:  Domain Name:  Runt domain
Description:  The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia []. The gene is highly similar to the Drosophila melanogastersegmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [].The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction. In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal regionrich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters. The protein is a heterodimer of alpha- and beta-subunits. The alpha-subunit binds DNA as a monomer, and appears to have a role in the development ofnormal hematopoiesis. CBF is a nuclear protein expressed in numerous tissue types, except brain and heart; highest levels have been found to occur in thymus, bone marrow and peripheral blood.This domain occurs towards the N terminus of the proteins in this entry. Short Name:  Runt_dom
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF00853
PS51062

2 Found Ins

DB identifier Type Name
IPR016554 Family Runt-related transcription factor RUNX
IPR000040 Family Acute myeloid leukemia 1 protein (AML1)/Runt

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR013524
GO:0003700 IPR013524
GO:0006355 IPR013524

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR013524
GO:0003700 IPR013524
GO:0006355 IPR013524

1 Parent Features

DB identifier Type Name
IPR012346 Domain p53/RUNT-type transcription factor, DNA-binding domain

10 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
28854.m000050 B9T9P1 PAC:16801860 Ricinus communis 435  
Kalax.0154s0045.1.p PAC:32592634 Kalanchoe laxiflora 186  
Kalax.0232s0055.1.p PAC:32596218 Kalanchoe laxiflora 117  
Kaladp0093s0141.1.p PAC:35772592 Kalanchoe fedtschenkoi 117  
Sobic.003G277700.1.p C5XIB4 PAC:37916103 Sorghum bicolor 369  
SbRio.03G299900.1.p PAC:38986943 Sorghum bicolor Rio 369  
CepurR40.12G104900.1.p PAC:43015314 Ceratodon purpureus R40 557  
CepurGG1.12G108100.1.p PAC:43053772 Ceratodon purpureus GG1 557  
SbiRTX430.03G299500.1.p PAC:43541989 Sorghum bicolor RTx430 369  
SbiBTX642.03G297500.1.p C5XIB4 PAC:44427658 Sorghum bicolor BTx642 369  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7651838