Protein Domain : IPR016700

Type:  Family Name:  3-hydroxyanthranilate 3, 4-dioxygenase, metazoan
Description:  This group represents a 3-hydroxyanthranilate 3,4-dioxygenase found in metazoan species, especially animals. 3-Hydroxyanthranilic acid 3,4-dioxygenase (3HAO) is a non-heme ferrous extradiol dioxygenase in the kynurenine pathway from tryptophan. It catalyzes the conversion of 3-hydroxyanthranilate (HAA) to quinolinic acid (QUIN), an endogenous neurotoxin, via the activation of N-methyl-D-aspartate (NMDA) receptors and the precursor of NAD+ biosynthesis []. Kynurenine pathway metabolism has been implicated in neurological disease []. Short Name:  3hydroanth_dOase_met
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0 Child Features

1 Contains

DB identifier Type Name
IPR011051 Domain RmlC-like cupin domain

1 Cross References

Identifier
PIRSF017681

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0000334 IPR016700
GO:0046872 IPR016700
GO:0055114 IPR016700
GO:0005737 IPR016700

4 Ontology Annotations

GO Term Gene Name
GO:0000334 IPR016700
GO:0046872 IPR016700
GO:0055114 IPR016700
GO:0005737 IPR016700

1 Parent Features

DB identifier Type Name
IPR010329 Family 3-hydroxyanthranilic acid dioxygenase

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16522801
            1422788