Protein Domain : IPR029822

Type:  Family Name:  Transcription factor JunB
Description:  Transcription factor JunB is a member of the transcription factor activator protein (AP)-1 family, comprising Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), ATF (ATFa, ATF-2 and ATF-3) and JDP (JDP-1 and JDP-2) family members []. They are basic leucine zipper transcription factors that play a central role in regulating gene transcription in various biological processes []. JunB may serve as a biomarkers for prognosis of breast cancer [].AP-1 proteins have a alpha-helical bZIP domain, which contains a basic DNA-binding region and regularly spaced leucine residues known as the leucine zipper motif []. They have similar protein structure and can either form homodimers or form heterodimers with other AP-1 proteins (predominantly with Jun proteins), which can then bind to TRE-like sequences (consensus sequence 5'-TGAG/CTCA-3') []. Each of these proteins are expressed in different tissues and can be regulated in different ways, which means that every cell type has a complex mixture of AP-1 dimers with subtly different functions []. Short Name:  JunB
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11462:SF37

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR029822
GO:0003700 IPR029822
GO:0006357 IPR029822
GO:0051726 IPR029822

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR029822
GO:0003700 IPR029822
GO:0006357 IPR029822
GO:0051726 IPR029822

1 Parent Features

DB identifier Type Name
IPR002112 Family Transcription factor Jun

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12424143
            23787991
            15564374
            24073962