Protein Domain : IPR030757

Type:  Family Name:  Monocarboxylate transporter 1
Description:  Monocarboxylate transporter 1 (MCT1), also known as SLC16A1, belongs to the MCT family. It facilitates unidirectional proton-linked transport of L-lactate across the plasma membrane [, ]. Several natural occurring substrates for MCT1 have been found, including L-lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate []. Inhibition of MCT1 during T lymphocyte activation results in selective and profound inhibition of the extremely rapid phase of T cell division essential for an effective immune response. Therefore, MCT1 has been used as a target for immunosuppressive therapy [, ].Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [, ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities []. MCT1-4 have been linked to cancer maintenance and aggressiveness []. Short Name:  MCT1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11360:SF24

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008028 IPR030757
GO:0015129 IPR030757
GO:0015718 IPR030757
GO:0005887 IPR030757

4 Ontology Annotations

GO Term Gene Name
GO:0008028 IPR030757
GO:0015129 IPR030757
GO:0015718 IPR030757
GO:0005887 IPR030757

1 Parent Features

DB identifier Type Name
IPR004743 Family Monocarboxylate transporter

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9425115
            22131303
            22407107
            7980443
            16370372
            16455256