Protein Domain : IPR030759

Type:  Family Name:  Monocarboxylate transporter 3
Description:  Monocarboxylate transporter 3 (MCT3), also known as SLC16A8, belongs to the MCT family. It may play an important role in facilitating the transport of glycolytically derived lactic acid out of the retina [].Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [, ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities []. MCT1-4 have been linked to cancer maintenance and aggressiveness []. Short Name:  MCT3
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11360:SF26

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008028 IPR030759
GO:0015129 IPR030759
GO:0015718 IPR030759
GO:0005887 IPR030759

4 Ontology Annotations

GO Term Gene Name
GO:0008028 IPR030759
GO:0015129 IPR030759
GO:0015718 IPR030759
GO:0005887 IPR030759

1 Parent Features

DB identifier Type Name
IPR004743 Family Monocarboxylate transporter

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9425115
            22131303
            22407107