Protein Domain : IPR030756

Type:  Family Name:  Monocarboxylate transporter 4
Description:  Monocarboxylate transporter 4 (MCT4), also known as SLC16A3, belongs to the MCT family. MCT4 is one the key transporters involved in the regulation of lactate metabolism in skeletal muscle. It is highly expressed in glycolytic fast-twitch muscle, and it is involved in the extrusion of lactate from muscle cells [, ]. It is also expressed in the small intestine, where it may mediate butyrate transport [].Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [, ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities []. MCT1-4 have been linked to cancer maintenance and aggressiveness []. Short Name:  MCT4
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11360:SF27

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008028 IPR030756
GO:0015129 IPR030756
GO:0015718 IPR030756
GO:0005887 IPR030756

4 Ontology Annotations

GO Term Gene Name
GO:0008028 IPR030756
GO:0015129 IPR030756
GO:0015718 IPR030756
GO:0005887 IPR030756

1 Parent Features

DB identifier Type Name
IPR004743 Family Monocarboxylate transporter

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9425115
            22131303
            22407107
            10926847
            9632638
            23344966