1 Parent Features
DB identifier | Type | Name |
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IPR004625 | Family | Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase |
Type: | Family | Name: | Pyridoxal kinase PdxY |
Description: | Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].Pyridoxal kinase PdxY (Escherichia coli pyridoxal kinase 2 or ePL kinase 2) phosphorylates B6 vitamers. PdxY acts in the salvage pathway of pyridoxal 5'-phosphate biosynthesis []. It has been shown to have some pyridoxal (PL) kinase activity, but at a greatly reduced level compared tothe enzyme expressed by the pdxK gene (ePL kinase 1) []. | Short Name: | Pyridoxal_kinase_PdxY |
DB identifier | Type | Name |
---|---|---|
IPR004625 | Family | Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase |