Protein Domain : IPR012013

Type:  Family Name:  Integrin beta-4 subunit
Description:  Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. The integrin receptors are composed of alpha and beta subunit heterodimers. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.The beta 4 subunit differs from other beta subunits in three ways: 1) the cytoplasmic domain is larger; 2) it lacks some of the conserved cysteines in the extracellular domain; and 3) it has a unique domain organisation.Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells []. Integrin beta-4 is required for the regulation of keratinocyte polarity and motility [].For additional information please see [, , , , , , , ]. Short Name:  Integrin_bsu-4
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0 Child Features

7 Contains

DB identifier Type Name
IPR002035 Domain von Willebrand factor, type A
IPR003961 Domain Fibronectin type III
IPR013111 Domain EGF-like domain, extracellular
IPR003644 Domain Na-Ca exchanger/integrin-beta4
IPR013032 Conserved_site EGF-like, conserved site
IPR012896 Domain Integrin beta subunit, tail
IPR002369 Domain Integrin beta subunit, N-terminal

2 Cross Referencess

Identifier
PTHR10082:SF6
PIRSF002513

0 Found In

7 GO Annotations

GO Term Gene Name
GO:0004872 IPR012013
GO:0007155 IPR012013
GO:0007160 IPR012013
GO:0007229 IPR012013
GO:0031581 IPR012013
GO:0048870 IPR012013
GO:0008305 IPR012013

7 Ontology Annotations

GO Term Gene Name
GO:0004872 IPR012013
GO:0007155 IPR012013
GO:0007160 IPR012013
GO:0007229 IPR012013
GO:0031581 IPR012013
GO:0048870 IPR012013
GO:0008305 IPR012013

1 Parent Features

DB identifier Type Name
IPR015812 Family Integrin beta subunit

0 Proteins

15 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12297042
            14689578
            2467745
            12234368
            12361595
            9166594
            9402004
            2311578
            2311577
            2542022
            15157503
            1976638
            7982032
            12482924
            19403692