Protein Domain : IPR012896

Type:  Domain Name:  Integrin beta subunit, tail
Description:  Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. The integrin receptors are composed of alpha and beta subunit heterodimers. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.This entry represents the tail domain of the integrin beta subunit. It forms a four-stranded beta-sheet that contains parallel and anttparallel strands and faces an alpha helix found at the N terminus of this domain []. Interactions between the alpha-helix and the beta-sheet are mostly hydrophobic and involve a disulphide bond. The rear of the beta sheet is covered with a long A-B loop. Short Name:  Integrin_bsu_tail
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF07965
SSF69687

5 Found Ins

DB identifier Type Name
IPR012013 Family Integrin beta-4 subunit
IPR015436 Family Integrin beta-6 subunit
IPR015439 Family Integrin beta-2 subunit
IPR015812 Family Integrin beta subunit
IPR015437 Family Integrin beta-7 subunit

0 GO Annotation

0 Ontology Annotations

0 Parent Features

12 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Thecc1EG043645t1 A0A061FW22 PAC:27443112 Theobroma cacao 98  
Manes.04G001900.1.p A0A2C9VYC2 PAC:32328012 Manihot esculenta 73  
Brdisv1BdTR9K1014234m.p PAC:34655107 Brachypodium distachyon BdTR9k 116  
evm.model.Scaffold_1920.25 PAC:37845329 Coffea arabica 77  
Desop.0211s0807.1.p PAC:39681537 Descurainia sophioides 491  
Clevi.0016s0298.1.p PAC:39745664 Cleome violacea 412  
Manes.04G001900.2.p PAC:41867099 Manihot esculenta 101  
Manes.04G001900.3.p PAC:41867100 Manihot esculenta 97  
Thecc.10G100300.1.p A0A061FW22 PAC:42024461 Theobroma cacao 98  
EL10Ac4g10278.1 PAC:43400787 Beta vulgaris 328  
Nycol.B00395.1.p PAC:44507447 Nymphaea colorata 157  
Clevi.0011s0917.1.p PAC:45708005 Cleome violacea 403  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12297042
            14689578
            2467745
            12234368
            12361595
            11546839