Protein Domain : IPR016849

Type:  Family Name:  Histone acetyltransferase Rtt109
Description:  Rtt109, also known as KAT11, is a recently characterised fungal-specific histone acetyltransferase (HAT) that modifies histone H3 lysine 56 (H3K56) to promote genome stability and resistance to a variety of DNA-damaging agents. Rtt109 does not show sequence conservation with other known HATs and depends on association with either of two histone chaperones, Asf1 or Vps75, for HAT activity [, , ].Rtt109-type HAT domain consists of a core HAT subdomain, which binds the acetyl-CoA cofactor. A second subdomain, the activation subdomain, is tightly associated with the HAT subdomain. Autoacetylation of a lysine within the activation subdomain is required for stabilising the interaction between the two subdomains and is essential for catalysis. The Rtt109-type HAT domain contains eight beta strands and nine alpha helices and displays mixed three-layered alpha/beta architecture with eight beta strands sandwiched by five alpha helices (alpha1-alpha5) from one side, and four alpha helices (alpha6-alpha9) from the other side [, , ]. Short Name:  Rtt109
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PTHR31571:SF2
PIRSF027124
PS51728

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0010484 IPR016849
GO:0016573 IPR016849
GO:0043618 IPR016849
GO:0005634 IPR016849

4 Ontology Annotations

GO Term Gene Name
GO:0010484 IPR016849
GO:0016573 IPR016849
GO:0043618 IPR016849
GO:0005634 IPR016849

1 Parent Features

DB identifier Type Name
IPR013178 Family Histone acetyltransferase Rtt109/CBP

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18568037
            18707894
            18719104