Protein Domain : IPR002297

Type:  Family Name:  DNA-directed DNA-polymerase, family A, mitochondria
Description:  DNA carries the biological information that instructs cells how to exist in an ordered fashion. Accurate replication is thus one of the mostimportant events in the cell life cycle. This function is mediated by DNA-directed DNA-polymerases, which add nucleotide triphosphate (dNTP)residues to the 5'-end of the growing DNA chain, using a complementary DNA as template. Small RNA molecules are generally used as primers forchain elongation, although terminal proteins may also be used.DNA-dependent DNA-polymerases have been grouped into families, denoted A, B and X, on the basis of sequence similarities [, ]. Members of family A, which includes bacterial and bacteriophage polymerases, share significant similarity to Escherichia colipolymerase I; hence family A is also known as the pol I family. The bacterial polymerases also contain an exonuclease activity, which is coded for in the N-terminal portion. The yeast gamma polymerases show some similarity to the prokaryotic nuclear polymerases of family A, but their function is restricted to mitochondrial DNA replication and repair []. Short Name:  DNA-dir_DNA_pol_A_mt

0 Child Features

3 Contains

DB identifier Type Name
IPR001098 Domain DNA-directed DNA polymerase, family A, palm domain
IPR012337 Domain Ribonuclease H-like domain
IPR019760 Conserved_site DNA-directed DNA polymerase, family A, conserved site

3 Cross Referencess

Identifier
PTHR10267
PIRSF000797
PR00867

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR002297
GO:0006260 IPR002297
GO:0005760 IPR002297

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR002297
GO:0006260 IPR002297
GO:0005760 IPR002297

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2196557
            3479792
            3522588