Protein Domain : IPR017979

Type:  Conserved_site Name:  GPCR, family 3, conserved site
Description:  G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.This entry represents three conserved sites found in family 3 GPCR receptor proteins. The first conserved site is centred around a highly conserved hydrophobic segment in the central part of the N-terminal extracellular region; the second conserved site is centred around a cluster of six cysteines in the C-terminal part of the extracellular domain; the third conserved site is centred around the C-terminal part of the cytoplasmic loop between the fifth and sixth transmembrane domains. Short Name:  GPCR_3_CS
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PS00979
PS00980
PS00981

13 Found Ins

DB identifier Type Name
IPR000337 Family GPCR, family 3
IPR017978 Domain GPCR, family 3, C-terminal
IPR011500 Domain GPCR, family 3, nine cysteines domain
IPR002457 Family GPCR, family 3, gamma-aminobutyric acid receptor, type B2
IPR000112 Family GPCR, family 3, metabotropic glutamate receptor 6
IPR000162 Family GPCR, family 3, metabotropic glutamate receptor
IPR000144 Family GPCR, family 3, metabotropic glutamate receptor 8
IPR001234 Family GPCR, family 3, metabotropic glutamate receptor 3
IPR001458 Family GPCR, family 3, metabotropic glutamate receptor 2
IPR001786 Family GPCR, family 3, metabotropic glutamate receptor 4
IPR001883 Family GPCR, family 3, metabotropic glutamate receptor 7
IPR000202 Family GPCR, family 3, metabotropic glutamate receptor 5
IPR001256 Family GPCR, family 3, metabotropic glutamate receptor 1

3 GO Annotations

GO Term Gene Name
GO:0004930 IPR017979
GO:0007186 IPR017979
GO:0016021 IPR017979

3 Ontology Annotations

GO Term Gene Name
GO:0004930 IPR017979
GO:0007186 IPR017979
GO:0016021 IPR017979

0 Parent Features

0 Proteins

12 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8170923
            16753280
            23020293
            12679517
            8081729
            15914470
            18948278
            8255296
            10773016
            1309649
            9292726
            17266540