Protein Domain : IPR017978

Type:  Domain Name:  GPCR, family 3, C-terminal
Description:  G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.This entry represents the C-terminal region of family 3 GPCR receptor proteins, which contains the seven transmembrane region. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness []. Short Name:  GPCR_3_C
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0 Child Features

1 Contains

DB identifier Type Name
IPR017979 Conserved_site GPCR, family 3, conserved site

2 Cross Referencess

Identifier
PF00003
PS50259

15 Found Ins

DB identifier Type Name
IPR000337 Family GPCR, family 3
IPR002455 Family GPCR, family 3, gamma-aminobutyric acid receptor, type B
IPR002956 Family Bride of sevenless protein
IPR004073 Family GPCR, family 3, vomeronasal receptor, type 2
IPR002456 Family GPCR, family 3, gamma-aminobutyric acid receptor, type B1
IPR002457 Family GPCR, family 3, gamma-aminobutyric acid receptor, type B2
IPR000112 Family GPCR, family 3, metabotropic glutamate receptor 6
IPR000162 Family GPCR, family 3, metabotropic glutamate receptor
IPR000144 Family GPCR, family 3, metabotropic glutamate receptor 8
IPR001234 Family GPCR, family 3, metabotropic glutamate receptor 3
IPR001458 Family GPCR, family 3, metabotropic glutamate receptor 2
IPR001786 Family GPCR, family 3, metabotropic glutamate receptor 4
IPR001883 Family GPCR, family 3, metabotropic glutamate receptor 7
IPR000202 Family GPCR, family 3, metabotropic glutamate receptor 5
IPR001256 Family GPCR, family 3, metabotropic glutamate receptor 1

3 GO Annotations

GO Term Gene Name
GO:0004930 IPR017978
GO:0007186 IPR017978
GO:0016021 IPR017978

3 Ontology Annotations

GO Term Gene Name
GO:0004930 IPR017978
GO:0007186 IPR017978
GO:0016021 IPR017978

0 Parent Features

17 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Sphfalx0044s0085.2.p PAC:32619987 Sphagnum fallax 444  
Sphfalx0044s0085.1.p PAC:32619986 Sphagnum fallax 612  
Sphmag19G044800.3.p PAC:41944280 Sphagnum magellanicum 444  
Sphmag19G044800.4.p PAC:41944279 Sphagnum magellanicum 612  
Sphmag19G044800.1.p PAC:41944278 Sphagnum magellanicum 612  
Sphmag19G044800.2.p PAC:41944281 Sphagnum magellanicum 444  
Sphfalx19G043200.5.p PAC:41980521 Sphagnum fallax 612  
Sphfalx19G043200.3.p PAC:41980522 Sphagnum fallax 444  
Sphfalx19G043200.4.p PAC:41980523 Sphagnum fallax 444  
Sphfalx19G043200.1.p PAC:41980520 Sphagnum fallax 612  
Thupl.29377767s0001.1.p PAC:44991875 Thuja plicata 383  
Thupl.29377767s0001.2.p PAC:44991876 Thuja plicata 383  
Thupl.29378652s0002.3.p PAC:44944178 Thuja plicata 358  
Thupl.29378652s0002.4.p PAC:44944179 Thuja plicata 358  
Thupl.29378652s0002.2.p PAC:44944177 Thuja plicata 371  
Thupl.29378652s0002.1.p PAC:44944176 Thuja plicata 371  
Ceric.19G053100.1.p PAC:50575165 Ceratopteris richardii 347  

13 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8170923
            16753280
            23020293
            12679517
            8081729
            15914470
            18948278
            8255296
            10773016
            1309649
            9292726
            17266540
            16076846